It’s 1912 and the United States is just beginning to emerge as a world power. The floating City of Columbia stands as a symbol of American ideals, launched with great fanfare to the cheers of a captivated public. But what begins as an endeavor of hope soon turns to disaster, as the city disappears into the clouds.

Pinkerton agent Booker DeWitt, is sent to Columbia to rescue Elizabeth, a young woman imprisoned there since childhood. He will develop a relationship with her, thus augmenting his abilities with hers so that the pair may escape from the city that is literally falling from the sky. DeWitt must learn to fight his enemies in high-speed Sky-Line battles, engage in combat both indoors and amongst the clouds, and harness the power of dozens of new weapons and abilities.